2026-07-15 · 8 min read · quality-coa

How to Read an HPLC Chromatogram and Mass Spectrometry (MS) COA Before Bulk Purchasing

Retention time, peak area, observed mass — what each field means and the red flags that suggest a recycled report.

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An HPLC report shows absorbance against retention time. Purity is the main peak's area as a percentage of total peak area.

The MS report confirms identity: the observed mass should match the theoretical molecular weight within the instrument's tolerance.

Red flags: no batch number, a date far older than the batch, or identical chromatograms across different lots. Always ask for the batch-matched report.

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